Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical objectives and you may pharmacology out of curcumin
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the biggest element of new red-colored color out-of turmeric, an enthusiastic Indian spruce that’s extracted from this new rhizome of the warm bush Curcuma longa, and therefore is one of the Zingiberaceae loved ones. Within this section, i discuss the pharmacological facts from curcumin and you may explore the unit basics for those facts. We next opinion the new shown and you can possible medical uses out-of curcumin. Curcumin known historically once the a therapeutic representative, however, its system of action was intricate. This new pharmacological effects of curcumin seem to be caused by an effective synergism out of companies of weak biochemical connections with numerous physiological purpose when you look at the interrelated signaling paths. These types of objectives are nutrients such as for instance cyclooxygenase, lipoxygenase and you can protein kinases, and you will transcription issues such as NF-?B, STAT and Nrf2. Modulation ones molecules impacts downstream affectors that produce this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial facts regarding curcumin. These effects have been tested inside logical samples of curcumin for aches and inflammatory illness, disease, Alzheimer condition, aerobic disorder, and you may diabetes. Brand new trials have used adjustable dosages out of curcuminwith different wavelengths and you may period, into general conclusion you to definitely higher amounts out-of curcumin in the number of g are required to receive therapeutic outcomes. Read more
Curcumin: Synthesis, Emerging Role into the Aches Management and you may Health Effects
Guide Section Samples of plant-derived pharmaceuticals which have end up being the desire out-of carried on and you can exponential research and you can development appeal possess, at this point, been somewhat scarce. After years, the last 2 decades was in fact characterized by an effective 100-fold increase in exactly how many scientific articles had written annually you to are out-of advantages on the usage of curcumin for the biomedicine. Read more
Framework, synthesis and you may biological circumstances out of curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some potential pharmacological consequences and may provides therapeutic applications in lot of disease states, as discussed in more detail in the last section. However, the possibility medical efficacy regarding curcumin is bound of the their physicochemical attributes out of terrible liquid solubility and you may instability, hence lead to reduced bioavailability. Prodrugs off curcumin provide an easy way to update of your biopharmaceutical and you will pharmacokinetic services, and could allow it to be exploitation of one’s pharmacological aftereffects of curcumin. Inside part, i basic opinion the newest physicochemical and you will pharmacokinetics away from curcumin. We after that describe the style of curcumin prodrugs that have increased drinking water solubility and you can increased chemical balances and this can be converted back into 100 % free curcumin through to bioactivation in vivo. I highlight latest success here, with a concentrate on the framework, synthesis and you can comparison out-of prodrugs predicated on promoieties Latin Women Date dating app download and additionally amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric materials like hyaluronic acid and you may polyethylene glycol. This section has got the basis for optimisation of physicochemical and you will biopharmaceutical functions therefore the biological facts regarding curcumin prodrugs, into the mission having fun with of those curcumin types inside the health-related applications. Read more